Medical University of Bialystok. Research & Science.

Research activity

Molecular basis of antitumour drug-DNA interactions
Synthesis and structure-activity studies of cytotoxic minor groove binders and topoisomerase I/II inhibitors
Design and synthesis anticancer prodrugs which are inactive until locally activated by some tumour-associated enzyme.

Techniques

Organic synthesis
Molecular modelling
Electrophoretic and chromatographic techniques

Publications

Czarnomysy R., Bielawski K., Muszyńska A., Bielawska A., Gornowicz A.: Biological evaluation of dimethylpyridine-platinum complexes with potent antiproliferative activity. J. Enzyme Inhib. Med. Chem., 16 (2016)
Lepiarczyk M., Kałuża Z., Bielawska A., Czarnomysy R., Gornowicz A., Bielawski K.: Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives in human breast cancer cells. Arch. Pharm. Res., 38 (5) s. 628-641 (2015)
Czarnomysy R., Bielawska A., Muszyńska A., Bielawski K.: Effects of novel alkyl pyridine platinum complexes on apoptosis in Ishikawa endometrial cancer cells. Med. Chem., 11 (6) s. 540-550 (2015)
Mojzych M., Ceruso M., Bielawska A., Bielawski K., Fornal E., Supuran C. T.: New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors. Bioorg. Med. Chem., 23 (13) s. 3674-3680 (2015)
Plech T., Kaproń B., Paneth A., Wujec M., Czarnomysy R., Bielawska A., Bielawski K., Trotsko N., Kuśmierz E., Paneth P.: Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles. J. Enzyme Inhib. Med. Chem., 30 (6) s. 1021-1026 (2015)
Karczmarzyk Z., Wysocki W., Urbańczyk-Lipkowska Z., Kalicki P., Bielawska A., Bielawski K., Ławecka J.: Synthetic approaches for sulfur derivatives containing 1,2,4-triazine moiety: their activity for in vitro screening towards two human cancer cell lines. Chem. Pharm. Bull., 63 (7) s. 531-537 (2015)
Gornowicz A., Bielawska A., Czarnomysy R., Gabryel-Porowska H., Muszyńska A., Bielawski K.: The combined treatment with novel platinum (II) complex and anti-MUC1 increases apoptotic response in MDA-MB-231 breast cancer cells. Mol. Cell. Biochem., 408 (1-2) s. 103-113 (2015)
Gornowicz A., Kałuża Z., Bielawska A., Gabryel-Porowska H., Czarnomysy R., Bielawski K.: Cytotoxic efficacy of a novel dinuclear platinum(II) complex used with anti-MUC1 in human breast cancer cells. Mol. Cell. Biochem., 392 (1-2) s. 161-174 (2014)
Siwek A., Bielawska A., Maciorkowska E., Lepiarczyk M., Bielawski K., Trotsko N., Wujec M.: Cytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides. J. Enzyme Inhib. Med. Chem., 29 (2) s. 243-248 (2014)
Gęgotek A., Ambrożewicz E., Bielawska A., Bielawski K., Cyuńczyk M., Skrzydlewska E.: Dinuclear berenil-platinum (II) complexes as modulators of apoptosis in human MCF-7 and MDA-MB231 breast cancer cells. Anticancer Agents Med. Chem., 14 (8) s. 1179-1186 (2014)
Gabryel-Porowska H., Gornowicz A., Bielawska A., Wójcicka A., Maciorkowska E., Grabowska S. Z., Bielawski K.: Mucin levels in saliva of adolescents with dental caries. Med, Sci. Monit., 20 s. 72-77 (2014)
Mojzych M., Bielawska A., Bielawski K., Ceruso M., Supuran C.T.: Pyrazolo[4,3-e][1,2,4] triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity. Bioorg. Med. Chem., 22 (9) s. 2643-2647 (2014)
Mojzych M., Subertová V., Bielawska A., Bielawski K., Bazgier V., Berka K., Gacký T., Fornal E., Krystof V.: Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e] [1,2,4] triazines. Eur. J. Med. Chem., 78 s. 217-224 (2014)
Gornowicz A., Tokajuk G., Bielawska A., Maciorkowska E., Jabłoński R., Wójcicka A., Bielawski K.: The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries. Med. Sci. Monit., 20 s. 1095-1100 (2014)
Gęgotek A., Cyuńczyk M., Łuczaj W., Bielawska A., Bielawski K., Skrzydlewska E.: The redox status of human breast cancer cell lines (MCF-7 and MDA-MB231) treated with novel dinuclear berenil-platinum (II) complexes. Pharmazie, 69 (12) s. 923-928 (2014)