Działalność naukowa Zakładu Immunologii UMB obejmuje następujące kierunki badań:

1)      Ocena regulacji funkcji i czasu życia neutrofilów eksponowanych na związki endokrynnie czynne (EDCs)

2)      Znaczenie formowania zewnątrzkomórkowych sieci neutrofilowych (NETs) w stanach fizjologii i patologii.

3)      Mechanizmy pro-nowotworowego działania EDCs.

4)      Konsekwencje działania IFN-λ na linie komórkowe raka płaskonabłonkowego głowy i szyi.

Zadania badawcze realizowane są z wykorzystaniem technik biologii molekularnej, cytometrii przepływowej, mikroskopii fluorescencyjnej oraz metod immunoenzymatycznych.

Publikacje
 

• Jabłońska Ewa, Iwaniuk Agnieszka (Immu.), Ratajczak-Wrona Wioletta, Nowacka Kinga Henryka, Garley Marzena. Methylparaben modulates the relationship between autophagy and apoptosis in head and neck squamous cell carcinoma lines. Archivum Immunologiae et Therapiae Experimentalis 2026 : 74, 1, 13 pp., Article ID: 5

• Ratajczak-Wrona Wioletta, Aniszewska Aleksandra, Iwaniuk Agnieszka (Immu.), Garley Marzena, Wołczyński Sławomir, Skarżyński Dariusz Jan, Wrobel Jolanta, Zebrowska Agnieszka, Radziwon Piotr, Pucelik Barbara, Jabłońska Ewa. "Protective" imazalil vs its negative effects on immune system cells - neutrophils. Life  2026 : 16, 2, 15 pp., Article ID: 365

• Dąbrowska-Zagroba Dorota, Garley Marzena, Ratajczak-Wrona Wioletta, Grubczak Kamil, Radziwon Piotr, Wołczyński Sławomir, Jabłońska Ewa. Beneficial effects of antioxidants in regulating NET generation within the course of atherosclerosis. Archives of Medical Science 2025, 40 pp.

• Czaczkowska Luiza, Jabłońska Ewa, Ratajczak-Wrona Wioletta. Endocrine disruptors and breast cancer: a comprehensive review. Biomedicines. 2025 : 13, 11, 20 pp., Article ID: 2774

• Morawiec Maria-Laura, Kubina Robert, Jabłońska Ewa, Ratajczak-Wrona Wioletta, Stępień Sebastian, Gołębski Maciej, Mielczarek-Palacz Aleksandra. NETs - as predictors and targets of supportive therapy for cancer treatment. Frontiers in Immunology 2025 : 16, 27 pp., Article ID: 1666261

• Woźniak Łukasz, Mierzejewska Żaneta Anna, Borys Jan, Ratajczak-Wrona Wioletta, Antonowicz Bożena. Oxidative stress and biomarkers in craniofacial fractures healing: from lipid peroxidation to antioxidant therapies. Antioxidants 2025 : 14, 9, 22 pp., Article ID: 1070

• Ciołkiewicz Mariusz, Kuryliszyn-Moskal Anna, Jabłońska Ewa, Ratajczak-Wrona Wioletta, Wojciuk Mariusz, Klimiuk Piotr A. Neutrophil-to-lymphocyte ratio and fibroblast growth factor 21: their role in early cardiovascular involvement in rheumatoid arthritis. Journal of Clinical Medicine 2025 : 14, 24, 15 pp., Article ID: 8844

• Morawiec Maria-Laura, Kubina Robert, Stępień Sebastian, Smycz-Kubańska Marta, Królewska-Daszczyńska Patrycja, Ratajczak-Wrona Wioletta, Mielczarek-Palacz Aleksandra. Neutrophil extracellular traps in diseases of the female reproductive organs. Frontiers in Immunology 2025 : 16, 21 pp., Article ID: 1589329

• Jurczuk Aleksandra, Bałdyga Paulina, Płoński Adam, Jurczuk Maria, Garley Marzena. Toll-like receptors in inborn errors of immunity in children: diagnostic potential and therapeutic frontiers - a review of the latest data. Cells 2025 : 14, 23, 32 pp., Article ID: 1902

• Charkiewicz Angelika Edyta, Omeljaniuk Wioleta Justyna, Garley Marzena, Nikliński Jacek. Mercury exposure and health effects: what do we really know? International Journal of Molecular Sciences 2025 : 26, 5, 26 pp., Article ID: 2326

• Wasilewska Anna [in], Grabowska Marcelina, Moskalik-Kierat Dominika, Brzoza Martyna, Laudański Piotr, Garley Marzena. Immunological aspects of infertility - the role of KIR receptors and HLA-C antigen. Cells 2024 : 13, 1, 16 pp., Article ID 59

• Olejkowska Natalia, Gorczyca Iwona, Rękas Marek, Garley Marzena. Immunopathology of corneal allograft rejection and donor-specific antibodies (DSAs) as immunological predictors of corneal transplant failure. Cells 2024 : 13, 18, 12 pp., Article ID: 1532

• Omeljaniuk Wioleta Justyna, Garley Marzena, Pryczynicz Anna, Motyka Joanna, Charkiewicz Angelika Edyta, Milewska Elżbieta, Laudański Piotr, Miltyk Wojciech. NLRP3 inflammasome in the pathogenesis of miscarriages. International Journal of Molecular Sciences 2024 : 25, 19, 19 pp., Article ID: 10513

• Garley Marzena, Nowak Karolina, Jabłońska Ewa. Neutrophil microRNAs.  Biological Reviews  2024 : 99, 3, s. 864-877

• Wochyński Zbigniew, Majsterek Ireneusz, Gerszon Joanna, Wojtczak Radosław, Kabziński Jacek, Błaszczyk Jan, Sobiech Krzysztof A., Jabłońska Ewa, Ratajczak-Wrona Wioletta. Diagnostic value of the isoenzymatic index of lactate dehydrogenase in blood serum in a special process for training cadet pilots. Frontiers in Physiology 2024 : 15, 12 pp., Article ID: 1399446

• Garley Marzena. Unobvious neutrophil extracellular traps signification in the course of oral squamous cell carcinoma: current understanding and future perspectives. Cancer Control 2023 : 30, 8 pp.

• Garley Marzena, Omeljaniuk Wioleta Justyna, Motkowski Radosław, Ratajczak-Wrona Wioletta, Jabłońska Ewa, Filipkowski Daniel, Charkiewicz Angelika Edyta. Immunoaging - the effect of age on serum levels of NET biomarkers in men: a pilot study. International Journal of Occupational Medicine and Environmental Health 2023 : 36, 3, s. 333-348

• Charkiewicz Angelika Edyta, Omeljaniuk Wioleta Justyna, Nowak Karolina, Garley Marzena, Nikliński Jacek. Cadmium toxicity and health effects - a brief summary. Molecules 2023 : 28, 18, 16 pp., Article ID: 6620

• Iwaniuk Agnieszka (Immu.), Jabłońska Ewa. Neutrophils in health and disease: from receptor sensing to inflammasome activation. International Journal of Molecular Sciences 2023 : 24, 7, 16 pp, Article ID 6340

• Garley Marzena, Omeljaniuk Wioleta Justyna, Motkowski Radosław, Ratajczak-Wrona Wioletta, Jabłońska Ewa, Filipkowski Daniel, Charkiewicz Angelika Edyta. Immunoaging - the effect of age on serum levels of NET biomarkers in men: a pilot study. International Journal of Occupational Medicine and Environmental Health 2023 : 36, 3, s. 333-348

• Kozłowski Paweł, Śmiarowski Marcin, Przyborska Wiktoria, Zemlik Karolina, Małecka- Giełdowska Milena, Leszczyńska Aleksandra, Garley Marzena, Ciepiela Olga. Mild-to-moderate COVID-19 convalescents may present pro-longed endothelium injury. Jounal of Clinical Medicine. 2022 : 11, 21, 11 pp., Article ID: 6461

• Garley Marzena, Dziemiańczyk-Pakieła Dorota, Ratajczak-Wrona Wioletta, Pryczynicz Anna, Nowak Karolina, Łazarczyk Bogdan, Jabłońska Ewa. NETs biomarkers in saliva and serum OSCC patients: One hypothesis, two conclusions. Advances in Medical Sciences 2022 : 67, 1, s. 45-54

• Charkiewicz Angelika, Garley Marzena, Ratajczak-Wrona Wioletta, Jabłońska Ewa, Miltyk Wojciech, Motyka Joanna, Omeljaniuk Wioleta. The diagnostic potential of novel biomarkers of hypertension in men. Archives of Medical Science 2022 : 18, 6, s. 1666-1671

• Omeljaniuk Wioleta Justyna, Charkiewicz Angelika, Garley Marzena, Ratajczak-Wrona Wioletta, Czerniecki Jan, Jabłońska Ewa, Cechowska-Pasko Marzanna, Miltyk Wojciech. Bisphenol A: potential factor of miscarriage in women in the context of the phenomenon of neutrophil extracellular traps.Archivum Immunologiae et Therapiae Experimentalis 2022 : 70, 1, 10 pp., Article ID: 24

• Nowak Karolina, Jabłońska Ewa, Garley Marzena, Iwaniuk Agnieszka (Immu.), Radziwon Piotr, Wołczyński Sławomir, Ratajczak-Wrona Wioletta. Investigation of estrogen-like effects of parabens on human neutrophils. Environmental Research 2022 : 214, 1, 12 pp., Article ID: 113893

• Jabłońska Ewa, Iwaniuk Agnieszka (Immu.), Ratajczak-Wrona Wioletta, Grubczak Kamil, Dziemiańczyk-Pakieła Dorota, Moniuszko Marcin, Nowak Karolina, Borys Jan, Garley Marzena. The promoting effect of neutrophil-derived BAFF molecule on the proliferation and life span of CAL-27 oral squamous carcinoma cells.Immunobiology 2022 : 227, 5, 11 pp, Article ID 152247

• Garley Marzena, Jabłońska Ewa, Dziemiańczyk-Pakieła Dorota, Miltyk Wojciech, Ratajczak-Wrona Wioletta, Borys Jan, Moniuszko Marcin, Grubczak Kamil. LDGs versus NDGs in patients with oral squamous cell carcinoma (OSCC).Cytokine 2021 : 137, 9 pp, Article ID 155311

• Garley Marzena, Jabłońska Ewa, Miltyk Wojciech, Grubczak Kamil, Surażyński Arkadiusz, Ratajczak-Wrona Wioletta, Grudzińska Małgorzata, Nowacka Kinga, Moniuszko Marcin, Pałka Jerzy, Borys Jan, Dziemiańczyk-Pakieła Dorota.Cancers cells in traps? The pathways of NETs formation in response to OSCC in humans - a pilot study.Cancer Control 2020 : 27, 1, 10 pp

• Nowak Karolina [S.D.], Jabłońska Ewa, Radziwon Piotr, Ratajczak-Wrona Wioletta.Identification of a novel target for the action of endocrine disrupting chemicals: inhibitory effect of methylparaben on human neutrophil functions.Environmental Science and Pollution Research 2020 : 27, s. 6540-6548

• Jabłońska Ewa, Garley Marzena, Surażyński Arkadiusz, Grubczak Kamil, Iwaniuk Agnieszka, Borys Jan, Moniuszko Marcin, Ratajczak-Wrona Wioletta.Neutrophil extracellular traps (NETs) formation induced by TGF-beta in oral lichen planus - Possible implications for the development of oral cancer.Immunobiology 2020 : 225, 2, Article ID 151901, 10pp.

• Ratajczak-Wrona Wioletta, Jabłońska Ewa, Garley Marzena, Nowak Karolina, Dąbrowska Dorota, Radziwon Piotr.Regulation of NO production by MAPK dual-specificity phosphatases (DUSP) in human neutrophils exposed to N-nitrosodimethylamine.Indian Journal of Experimental Biology 2020 : 58, 7, s. 437-444

• Ratajczak-Wrona Wioletta, Rusak Małgorzata, Nowak Karolina [S.D.], Dąbrowska Milena, Radziwon Piotr, Jabłońska Ewa.Effect of bisphenol A on human neutrophils immunophenotype.Scientific Reports 2020 : 10, Article ID: 3083, 10pp.

• Nowak Karolina, Jabłońska Ewa, Garley Marzena, Radziwon Piotr, Ratajczak-Wrona Wioletta.Investigation methylparaben-induced estrogen-like regulation of iNOS-dependent nitric oxide production via NF-_KB signaling pathway - a preliminary study.W: 15^th Spring School on Immunology. Ettal, Bavaria. March 10- March 15, 2019.

• Nowak Karolina, Jabłońska Ewa, Ratajczak-Wrona Wioletta.Immunomodulatory effects of synthetic endocrine disrupting chemicals on the development and functions of human immune cells.Environment International 2019 : 125, s. 350-364

• Ratajczak-Wrona Wioletta, Nowak Karolina, Garley Marzena, Grubczak Kamil, Dąbrowska Dorota, Iwaniuk Agnieszka, Wilk Sara, Moniuszko Marcin, Czerniecki Jan, Wołczyński Sławomir, Jabłońska Ewa.Expression of serine proteases in neutrophils from women and men: Regulation by endocrine disruptor bisphenol A.Environmental Toxicology and Pharmacology 2019 : 71, Article number 103212, 10 pp.

• Iwaniuk Agnieszka, Grubczak Kamil, Ratajczak-Wrona Wioletta, Garley Marzena, Nowak Karolina, Jabłońska Ewa.N-nitrosodimethylamine (NDMA) induced apoptosis dependent on Fas/FasL complex in human leukocytes.Human & Experimental Toxicology 2019 : 38, 5, s. 578-587

• Ratajczak-Wrona Wioletta, Nowak Karolina, Garley Marzena, Tynecka Marlena, Jabłońska Ewa.Sex-specific differences in the regulation of inducible nitric oxide synthase by bisphenol A in neutrophils.Human & Experimental Toxicology 2019 : 38, 2, s. 239-246

• Dąbrowska Dorota, Jabłońska Ewa, Iwaniuk Agnieszka, Garley Marzena.Many ways-one destination: different types of neutrophils death.International Reviews of Immunology 2019 : 38, 1, s. 18-32

• Nowak Karolina, Jabłońska Ewa, Ratajczak-Wrona Wioletta. Neutrophils life under estrogenic and xenoestrogenic control.Journal of Steroid Biochemistry and Molecular Biology 2019 : 186, s. 203-211

• Ratajczak-Wrona Wioletta, Jabłońska Ewa. The signaling pathways in nitric oxide production by neutrophils exposed to N-nitrosodimethylamine. Letters in Drug Design & Discovery 2019 : 16, 2, s. 194-199

• Jabłońska Ewa, Raimondi Sara, Wieczorek Edyta, Król Magdalena, Gromadzińska Jolanta, Wąsowicz Wojciech, Socha Katarzyna, Borawska Maria Halina, Reszka Edyta.The impact of genetic polymorphism in selenoprotein encoding genes on the markers of oxidative stress, markers of glucose and lipid metabolism and liver enzymes activity - cross-sectional study.W: 2018 Scientific Meeting Italian Association for the Study of Trace Elements in Living Organisms (AISETOV), Ozzano Emilia, Bologna - October 12, 2018s. 33

• Nowak Karolina, Ratajczak-Wrona Wioletta, Jabłońska Ewa.The effect of methylparaben on particular functions of human neutrophils.W: 3rd Conference "Analytical methods to study oxidative damage, antioxidants and drugs" Advanced analytical chemistry for life sciences, Bialystok, 24-26.05.2018.s. 126

• Garley Marzena, Jabłońska Ewa.Heterogeneity among neutrophils.Archivum Immunologiae et Therapiae Experimentalis 2018 : 66, 1, s. 21-30

• Dąbrowska Dorota, Jabłońska Ewa, Garley Marzena, Sawicka-Powierza Jolanta, Nowak Karolina.The phenomenon of neutrophil extracellular traps in vascular diseases.Archivum Immunologiae et Therapiae Experimentalis 2018 : 66, 4, s. 273-281