• 25.09.2020 Zakład Chemii Nieorganicznej i Analitycznej

    Research & Science

     

    Research activity:

    • Estimation of the redox balance in different pathologies
    • Evaluation of the mechanisms of lipids, DNA and proteins oxidative damages
    • Evaluation of mechanisms of natural substances and drugs interactions and their influence on the redox balance
    •  

    Laboratory techniques:

    • spectroscopic techniques
      • spectrometry UV/VIS
      • spectrofluorimetry
    • separation techniques
      • liquid chromatography [HPLC-DAD, HPLC-UVVIS, HPLC-FLD]
      • gas chromatography [GC-FID, GC-NCD]
      • hybride techniques
      • liquid chromatography with mass spectrometry detection [LCMS; LCMS/MS]
      • gas chromatography with mass spectrometry detection [GCMS/MS]
    • electrophoretic techniques
      •  electrophoresis with immunoblot
     

     

    Publications:

     

    • Łuczaj W., Moniuszko A., Jarocka I., Pancewicz S., Andrisic L., Zarkovic N., Skrzydlewska E.: Tick-borne encephalitis - lipid peroxidation and its consequences. Scand. J. Clin. Lab. Invest., 2016,76: 1–9.
    • Moniuszko-Malinowska A., Łuczaj W., Jarocka-Karpowicz I., Pancewicz S., Zajkowska J., Andrisic L.,  Zarkovic N., Skrzydlewska E.:  Lipid peroxidation in the pathogenesis of neuroborreliosis. Free Rad. Biol. Med.,2016,96:255–263.
    • Łuczaj W., Gindzienska-Sieskiewicz E., Jarocka-Karpowicz I., Andrisic L., Sierakowski S., Zarkovic N., Waeg G. Skrzydlewska E.: The onset of lipid peroxidation in rheumatoid arthritis: consequences and monitoring. Free Rad. Res., 2016,50:304–313.
    • Semen K., Yelisyeyeva O., Jarocka-Karpowicz I., Kaminskyy D., Solovey L., Skrzydlewska E., Yavorskyi O.: Sildenafil reduces signs of oxidative stress in pulmonary arterial hypertension: Evaluation by fatty acid composition, level of hydroxynonenal and heart rate variability. Redox Biol., 2016,7:48-57.
    • Gęgotek A., Biernacki M., Ambrożewicz E., Surażyński A., Wroński A., Skrzydlewska E.: The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation. J. Dermatol. Sci., 2016, 81:107-117.
    • Biernacki M.,  Łuczaj W., Gęgotek A., Toczek M.,  Bielawska K.,  Skrzydlewska E.: Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. Toxicol.Appl.Pharm., 2016,301: 31–41.  
    • Biernacki M., Skrzydlewska E.: Metabolizm endokannabinoidów. Post. Hig. Med. Dośw., 2016,70: 830-843.  
    • Gęgotek A., Nikliński J., Zarkovic N., Zarkovic K., Waeg G., Łuczaj W., Charkiewicz R., Skrzydlewska E.: Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells. Red. Biol., 2016,9: 210-219.
    • Chwieśko A., Charkiewicz R., Nilkiński J., Łuczaj W., Skrzydlewska E., Milewski R., Baniukiewicz A., Wróblewski E., Rosołowski M., Dąbrowski A.:  Effects of different omeprazole dosing on gastric pH in nonvariceal upper gastrointestinal bleeding: A randomized prospective study. J. Dig. Dis., 2016, 33.   
    • Gęgotek A., Ambrożewicz E., Rybałtowska-Kawałko P., Skrzydlewska E.:  Rutin as an effective protector of fibroblasts against UVA irradiation. PeerJ, 2016, 2. 
    • Grzęda E., Schlicker E., Łuczaj W., Harasim E., Baranowska-Kuczko M., Malinowska M.: Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus. J. Physiol. Pharm., 2015,66:343-353.
    • Dobrzyńska I., Skrzydlewska E., Figaszewski Z.:  Effects of novel dinuclear cisplatinum(II) complexs on the electric properties of human Molt-4 leukemia cells. Cell. Biochem. Biophys., 2015,71: 1517-1523.
    • Kołodziejczyk L., Laszczyńska M., Masiuk M., Grabowska M., Skrzydlewska E.: Immunoexpression of intermediate filaments and morphological changes in the liver and bile duct of rats infected with Fasciola hepatica. Biotech. Histochem.,2015,1-9.  
    • Łuczaj W., Moniuszko A., Rusak M., Zajkowska J., Pancewicz S., Skrzydlewska E.: Peroxidative metabolism of arachidonic acid in the course of Lyme arthritis. Ann. Agric. Environ. Med., 2015,22: 433-437.
    • Łuczaj W., Jarocka-Karpowicz I., Bielawska K., Skrzydlewska E.: Sweet grass protection against oxidative stress formation in the rat brain. Metab. Brain Dis., 2015,30: 183-190.  
    • Gęgotek A., Skrzydlewska E.: Białka CNC w fizjologii i patologii. (CNC proteins in physiology and pathology). Post. Hig. Med. Dośw., 2015,69:729-743.
    • Gęgotek A., Skrzydlewska E.: Metabolizm i biologiczna rola czynnika aktywującego płytki krwi (PAF). Alergia Astma Immunologia, 2015,20:79-84.
    • Gęgotek A., Skrzydlewska E.: The role of transcription factor Nrf2 in skin cells metabolism. Arch. Dermatol. Res., 2015,307:385-396.
    • Dziomba S., Biernacki M., Olędzka I., Skrzydlewska E., Bączek T., Kowalski P.: Repetitive injection field-amplified sample stacking for cationic compounds determination. Talanta, 2014,125: 1-6.
    • Dobrzyńska I., Skrzydlewska E., Figaszewski Z.: Effects of novel dinuclear cisplatinum(II) complexs on the electric properties of human breast cancer cells. J. Membrane Biol., 2014, 247: 167-173.
    • Dobrzyńska I., Skrzydlewska E., Figaszewski Z.: Effects of nover dinuclear cisplatinum(II) complexes on the electrical properties of human Molt-4 leukemia cells. J. Cell Biochem. Biophys., 2014,14:375-379.
    • Bielawska K., Malinowska M., Cyuńczyk M.: Wpływ kumaryn na organizm człowieka. Bromat. Chem. Toksykol., 2014,2:213-221.
    • Gęgotek A., Cyuńczyk M., Łuczaj W., Bielawska A., Bielawski K., Skrzydlewska E.:  The redox status of human breast cancer cell lines (MCF-7 and MDA-MB231) treated with novel dinuclear berenil-platinum(II) complexes. Pharmazie, 2014,69: 923-928.
    • Gęgotek A., Ambrożewicz E., Bielawska A., Bielawski K., Cyuńczyk M., Skrzydlewska E.: Dinuclear berenil-platinum (II) complexes as modulators of apoptosis in human MCF-7 and MDA-MB231 breast cancer cells. Anti-Cancer Age. Med. Chem., 2014,14:1179-1186.
    • Dobrzyńska I., Szachowicz-Petelska B., Skrzydlewska E., Figaszewski Z.: Effect of sweet grass (Hierochloe odorata) on the physico-chemical propperties of liver cell membranes from rats intoxicated with ethanol. Environ. Tocixol. Pharmacol., 2013,35:247-253.  
    • Dobrzyńska I., Skrzydlewska E., Figaszewski Z.: Changes in electric properties of human breast cancer cells. J. Membrane Biol.,2013, 46:161-166.  
    • Szachowicz-Petelska B., Skrzydlewska B., Figaszewski Z.: Protective effect of black tea on integral membrane proteins in rat liver. Exp. Toxicol. Pathol., 2013,65:173-179.
    • Kołodziejczyk L., Jarocka I., Skrzydlewska E.: The efects of Fasciola hepatica  infection on the total antioxidant status (TAS) and the activity of proteases and their inhibitors in rat serum. Folia Biologica (Kraków), 2013,16:227-232.  
    • Malinowska M., Bielawska K.: Metabolizm I właściwości antyoksydacyjne kumaryn. Bromat. Chem. Toksykol., 2013, 3:393-403.
    • Ambrożewicz E., Augustyniak A., Gęgotek A., Bielwska K., Skrzydlewska E.: Black-currant protection against oxidative stress formation. J. Toxicol. Envoronmental 2013,76:293-1306.
    • Gęgotek A., Markowska A., Łuczaj W., Bielawska A., Bielawski K., Ambrożewicz E., Skrzydlewska E.: Effects of dinuclear berenil-platinum(II) complexes on fibroblasts redox status. Adv. Med. Sci., 2013,1-6.
    • Jarocka I., Gęgotek A., Bielawska., Bielawski K., Łuczaj W., Hodun T., Skrzydlewska E.: Effect of novel dinuclear platinum(II) complexes on redox status of MOLT-4 leukemic cells. Toxicol. Mech.Methods, 2013,23:641-649.
    • Łuczaj W., Stankiewicz-Kranc A., Milewska E., Roszkowska-Jakimiec W., Skrzydlewska E.: Effect of sweet grass extract against oxidative stress in rat liver and serum. Food Chem. Toxicol., 2012,50:135-140.
    • Szachowicz-Petelska B., Dobrzyńska I., Skrzydlewska E., Figaszewski Z.: Protective effect of blackcurrant of liver cell membrane of rats intoxicated with ethanol.  J. Membrane Biol., 2012,245:191-200.
    • Łuczaj W., Augustyniak A., Skrzydlewska E.: Tea and liver antioxidant capabilities in ethanol toxicity. Ed. V.R.Oreedy, Elsevier, TEA in Health and Disease Prevention, 2012,44:529-538.
    • Cyuńczyk M., Jarocka I., Hodun T.: Protective effect of sweet grass and black berries beverages on ethanol-induced disturbances in brain fatty acids. Prog. Health. Sci., 2012,2:130-139.
    • Augustyniak A., Bylińska A., Skrzydlewska E.: Age-dependent changes in the proteolytic-antiproteolytic balance after alcohol and black tea consumption. Toxicol. Mech. Methods, 2011,21:209-215.
    • Łuczaj W., Moniuszko A., Rusak M., Pancewicz S., Zajkowska J., Skrzydlewska E.: Lipid peroxidation products as potential bioindicators of Lyme arthritis. Eur. J. Clin. Microbiol. Inf. Diesease, 2011,30: 415-422.   
    • Kamianowska M., Szczepański M., Skrzydlewska E.. Effects of erythropoietin on ICAM-1 and PECAM-1 expressions on human umbilical vein endothelial cells subjected to oxidative stress. Cell Biochem. Func., 2011,29: 1-5.    
    • Ambrożewicz E., Zapora E., Szczepaniak M., Wnuczko K., Dziakowska I., Skrzydlewska E.: Porównanie działania czarnej i zielonej herbaty na komórki śródbłonka. Bromat. Chem. Toksykol., 2010,XLII,1:66-72.
    • Augustyniak A., Bartosz G., Cipak A., Duburs G., Horakova N., Łuczaj W., Majekova M., Odysseos A., Rackova L., Skrzydlewska E., Stefek M., Strtosova M., Tirzitis G., Venskutonis P., Viskupicove J., Vraka P., Zarkovic N.: Natural and synthetic antioxidants: An updated overvies. Free Radic. Res., 2010,44:1216-1262.
    • Łuczaj W., Zapora E., Skrzydlewska E.: Influence of green tea on erythrocytes antioxidant status of different age rats intoxicated with ethanol. Phytotherapy Res., 2010,24:424-428.
    • Breusing N., Grune T., Andrisic L., Ataly M., Bartosz G., Biasi F., Borovic S., Bravo L.,   Casals I., Lasillas R., Dinischiotu A., Drzewinska J., Faber H., Fauzi M., Gajewska A., Gambini J., Gradinaru D., Kokkola T., Lojek A., Łuczaj W., Margina D.,  Mascia C.,  Mateos R.,  Meinitzer A., Mitjavila M., Mrakovicic L., Munteanu M., Podborska M., Poli G., Sicinska P., Skrzydlewska E., Vina J., Wiswedel I., Zarkovic N., Zeler S., Spickett M.: An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples. Free Radic. Res., 2010,44: 1203-1215.
    • Szachowicz-Petelska B., Skrzydlewska E., Figaszewski Z.: Changes in protein comparison in erythrocyte membrane of etanol poisoned rats after administrations of teas. Anal. Lett., 2010,43:721-734.
    • Dobrzynska I., Szachowicz-Petelska B., Skrzydlewska E., Figaszewski Z.: Effect of L-carnitine on liver cell membranes in ethanol-intoxicated rats. Chem. Biol. Interact., 2010, 188: 44-51.
    • Augustyniak A., Skrzydlewska E.:  The influence of L-carnitine suplementation on the antioxidative abilities of serum and the central nervous system of ethanol-induced rats. Metab. Brain Dis., 2010,25:381-389
    • Stankiewicz-Kranc A., Miltyk W., Skrzydlewska E.: Comparison of influence of carmustine and New proline analog of nitrosourea on antioxidant system in Brest carcinoma cells (MCF-7). Drug Chem. Toxicol., 2010,33:55-63.   
    • Zapora E., Hołub M., Waszkiewicz E., Dąbrowska M., Skrzydlewska E.: Green tea effect on antioxidant status of erythrocytes and on haematological parameters in rats.  Bull. Vet. Inst. Pulawy, 2009,53:139-145.
    • Augustyniak A., Skrzydlewska E.: L-Carnitine in the lipid and protein protection against ethanol-induced oxidative stress. Alcohol,  2009,43:217-223.
    • Kornysova O., Stanius Z., Obelevicius K., Ragazinskiene O., Skrzydlewska E., Maruska A.: Capillary zone electrophoresis method for determination of bitter (alpha- and beta-) acids in hop (Humulus lupulus L.) cone extracts. Adv. Med. Sci.,2009,54,41-46.
    • Stankiewicz-Kranc A., Bielawska A., Bielawski K., Skrzydlewska E.: Proline analogue of nitrosourea as a New cytotoxic prodrug. Arch. Pharm. Chem. Life Sci., 2009,342:632-639.
    • Łuczaj W., Zapora E., Szczepański M., Wnuczko K., Skrzydlewska E.: Polyphenols action against oxidative stress formation In endothelial cells. Acta Pol. Pharm.,2009,66:617-624.  
    • Ambrożewicz E., Skrzydlewska E.: Antyoxidative  properties of Black currant. Farm. Przegl. Nauk.,2009,10:30-34.    
    • Augustyniak A., Stankiewicz A. Skrzydlewska E.: The influence of L-carnitine on oxidative modification of LDL In vitro. Toxicol. Mech. Methods, 2008,18:455-462.
    • Łuczaj W., Walerowicz T., Skrzydlewska E., Buszewski B.: Chromatographic examinations of tea protection against lipid oxidative modifications. Toxicol. Mech. Methods, 2008,18:483-490.
    • Siemieniuk E., Kołodziejczyk L., Skrzydlewska E.: Oxidative modifications of rat liver cell components during Fasciola hepatica infection. Toxicol. Mech. Methods, 2008,18:519-524.
    • Szachowicz-Petelska B., Dobrzyńska I., Skrzydlewska E., Figaszewski Z. Changes In phospholipid composition studiem by HPLC and electric properties of liver cell membrane of etanol-poisoned rats. Toxicol. Mech. Methods, 2008,18:525-530.
    • Dobrzyńska I., Szachowicz-Petelska B., Skrzydlewska E., Figaszewski Z.: Effects of green tea on physic-chemical properties of liver cell membranes of rats intoxicated with ethanol. Polish J. Environ. Stud., 2008,17:327-333.
    • Pancewicz A., Skrzydlewska E., Kondrusik M., Zajkowska J., Grygorczuk S., Świerzbińska R., Moniuszko A.: Stężenie witamin A, E, oraz C w surowicy krwi i płynie mózgowo-rdzeniowym chorych z kleszczowym zapaleniem mózgu – doniesienie wstępne. Przegl. Epidemiol., 2008,62:93-98.
    • Ostrowska J., Skrzydlewska E.: Starzenie- przyczyny i skutki. Pol. J. Cosmetol., 2008,11:25-39.
    • Dobrzyńska I., Szachowicz-Petelska B., Skrzydlewska B., Figaszewski Z.: Wpływ czarnej herbaty na właściwości fizyko-chemiczne błony komórek wątroby szczurów w różnym wieku w zatruciu etanolem. Błony Biol., monografia pod red. J. Gabrielskiej I P. Misiaka,2008,157-160.
    • Szachowicz- Petelska B., Dobrzyńska I., Skrzydlewska E., Figaszewski Z.: Zmiany zawartości składników błony erytrocytów I jej ładunku elektrycznego pod wpływem etanolu, acetaldehyde I octanu. Błony Biol., monografia pod red. J.Gabrielskiej I P. Misiaka, 2008,299-302.
    • Kamiński K., Bonda T., Wojtkowska I., Dobrzycki S., Kralisz P., Nowak K., Prokopczuk P., Skrzydlewska E., Kozuch M., Musiał W.J.: Oxidative stress and antioxidative defense parameters early after reperfusion therapy for acute myocardial infarction. Acute Card. Care, 2008,10, 121-126.