Medical University of Bialystok. Head.
  • 28.02.2023 Zakład Fizjologii i Patofizjologii Doświadczalnej

    Head

    Prof. Dr. Barbara Malinowska

    e-mail: barbara.malinowska@umb.edu.pl

    Head of the Department of Experimental Physiology and Pathophysiology

    Medical University of Białystok (Poland)

    Website: https://www.umb.edu.pl/en/s,21780/Head

     

    Key research interests:

    • Cannabinoid mechanisms in the regulation of the cardiovascular system under physiological and pathophysiological conditions.
    • Regulation of the cardiovascular system by presynaptic receptors.
    • Atypical ß-adrenoceptors: Search for models and investigation of ad hoc synthesized ligands.

     

    Scientific grants funded by National Science Centre (Poland):

    • Complex effects of cannabidiol on the cardiovascular system, oxidative stress and heart metabolism in experimental models of hypertension (OPUS; 2016 – 2019)
    • Role of endocannabinoids in the regulation of the cardiovascular system, oxidative stress and heart metabolism in the models of primary and secondary hypertension (OPUS; 2012 – 2016)

     

    Technologies/resources:

     

    List of publications from the last ten years:

    • Remiszewski P, Jarocka-Karpowicz I, Biernacki M, Jastrząb A, Schlicker E, Toczek M, Harasim-Symbor E, Pędzińska-Betiuk A, Malinowska B.: Chronic cannabidiol administration fails to diminish blood pressure in rats with primary and secondary hypertension despite its effects on cardiac and plasma endocannabinoid system, oxidative stress and lipid metabolism. Int J Mol Sci. 2020;21. pii: E1295.
    • Malinowska B.., Przegaliński E., Schlicker E.: Prof. Dr. med. Dr. h. c. mult. Manfred Göthert. Obituary. Pharmacol. Rep. 2020.
    • Göthert M., Bönisch H., Malinowska B., Schlicker E.: Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part II. Some contributions of Manfred Göthert. Pharmacol. Rep. 2020.
    • Malinowska B., Toczek M., Pędzińska-Betiuk A., Schlicker E. Cannabinoids in arterial, pulmonary and portal hypertension - mechanisms of action and potential therapeutic significance. Br J Pharmacol. 2019;176:10:1395-1411.
    • Kossakowski R., Schlicker E., Toczek M., Weresa J., Malinowska B.: Cannabidiol affects the Bezold-Jarisch reflex via TRPV1 and 5-HT3 receptors and has peripheral sympathomimetic effects in spontaneously hypertensive and normotensive rats. Front Pharmacol. 2019;10:500.
    • Baranowska-Kuczko M., Kozłowska H., Kloza M., Sadowska O., Kozłowski M., Kusaczuk M., Kasacka .I, Malinowska B.: Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities. J Hypertens. 2019. doi: 10.1097/HJH.0000000000002333.
    • Weresa J., Pędzińska-Betiuk A., Kossakowski R., Malinowska B.: Cannabinoid CB1 and CB2 receptors antagonists AM251 and AM630 differentially modulate the chronotropic and inotropic effects of isoprenaline in isolated rat atria. Pharmacol Rep. 2019;71:82-89.
    • Harasim-Symbor .E, Polak A., Pędzińska-Betiuk A., Weresa .J, Malinowska B., Lewandowska A., Kasacka .I, Chabowski. A.: Fatty acid amide hydrolase inhibitor (URB597) as a regulator of myocardial lipid metabolism in spontaneously hypertensive rats. Chem Phys Lipids. 2019;218:141-148.
    • Toczek M., Malinowska B. Enhanced endocannabinoid tone as a potential target of pharmacotherapy. Life Sci. 2018;204:20-45.
    • Biernacki M., Malinowska B., Timoszuk M., Toczek M., Jastrząb A., Remiszewski P., Skrzydlewska E.: Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. Prostaglandins Other Lipid Mediat. 2018;138:54-63.
    • Karpińska O., Baranowska-Kuczko M., Malinowska B., Kloza M., Kusaczuk M., Gęgotek A.,Golec P., Kasacka .I, Kozłowska H.: Mechanisms of l-alpha-lysophosphatidylinositol-induced relaxation in human pulmonary arteries. Life Sci. 2018;192:38-45.
    • Polak A., Harasim-Symbor E., Malinowska B., Kasacka .I, Lewandowska A, Chabowski A.: The endocannabinoid system affects myocardial glucose metabolism in the DOCA-Salt model of hypertension. Cell Physiol Biochem. 2018;46:727-739.
    • Grzęda E., Schlicker E., Toczek M., Zalewska I., Baranowska-Kuczko M., Malinowska B.: CB1 receptor activation in the rat paraventricular nucleus induces bi-directional cardiovascular effects via modification of glutamatergic and GABAergic neurotransmission. Naunyn Schmiedebergs Arch. Pharmacol. 2017;390:25-35.
    • Karpińska O., Baranowska-Kuczko M., Kloza M., Ambrożewicz E., Kozłowski T., Kasacka I., Malinowska B., Kozłowska H.: Activation of CB1 receptors by 2-arachidonoylglycerol attenuates vasoconstriction induced by U46619 and angiotensin II in human and rat pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2017;313:R883-R893.
    • Pędzińska-Betiuk A., Weresa J., Toczek M., Baranowska-Kuczko M., Kasacka I., Harasim- Symbor E., Malinowska B.: Chronic inhibition of fatty acid amide hydrolase by URB597  produces differential effects on cardiac performance in normotensive and hypertensive rats. Br J Pharmacol. 2017;74 :2114-2129.
    • Polak A., Harasim-Symbor E., Malinowska B., Kasacka I., Pędzińska-Betiuk A., Weresa J., Chabowski A. : The effects of chronic FAAH inhibition on myocardial lipid metabolism in normotensive and DOCA-salt hypertensive rats. Life Sci. 2017;183:1-10.
    • Kloza M.,Baranowska-Kuczko M., Malinowska B., Karpińska O., Harasim-Symbor E., Kasacka I., Kozłowska H.: The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on KCa2.3/KCa3.1-EDH-type relaxation in rat small mesenteric arteries. Vascul Pharmacol. 2017;99:65-73.
    • Baranowska-Kuczko M., Kozłowska H., Kloza M., Karpińska O., Toczek M., Harasim E., Kasacka I., Malinowska B.: Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats. Life Sci. 2016;151:288-99.
    • Toczek M., Baranowska-Kuczko M., Grzęda E., Pędzińska-Betiuk A., Weresa J., Malinowska B.: Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats. Pharmacol Rep. 2016;68:363-9.
    • Karabowicz P., Schlicker E., Pędzińska-Betiuk A., Kloza M., Malinowska B.: The adrenal medulla, not CB1 receptors, mediates the inhibitory effect of acute transverse aortic constriction on  the neurogenic vasopressor response. Life Sci. 2015;138:86-93.
    • Toczek M., Schlicker E., Grzęda E., Malinowska B.: Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats. Life Sci. 2015;138:78-85.
    • Grzęda E., Schlicker E., Luczaj W., Harasim E., Baranowska-Kuczko M, Malinowska B.: Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus. J Physiol Pharmacol. 2015 66:343-53.
    • Baranowska-Kuczko M., Kozłowska H., Kozłowski M., Schlicker E., Kloza M., Surażyński A., Grzęda E., Malinowska B.: Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. Naunyn-Schmiedeberg’s Arch. Pharmacol., 2014; 387:477-86.
    • Karabowicz P., Grzęda E., Baranowska-Kuczko M., Malinowska B.: Znaczenie endokannabinoidu 2-arachidonyloglicerolu w fizjologii i patofizjologii układu krążenia. Postępy Hig Med Dośw,  2014: 68:814-827.
    • Schlicker E., Pędzińska-Betiuk A., Kozłowska H., Szkaradek N., Zelaszczyk D., Baranowska-Kuczko M., Kieć-Kononowicz .K, Marona H, Malinowska B. :MH-3: evidence for non-competitive antagonism towards the low-affinity site of β1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2014;387:743-52.
    • Ilayan E., Feliszek M., Malinowska B., Schlicker E.: Do cannabinoids exhibit a tyramine-like effect? Naunyn Schmiedebergs Arch Pharmacol. 2013;386:1041-1046.
    • Kozłowska H., Baranowska-Kuczko M., Schlicker E., Kozłowski M., Kloza M., Malinowska B.: Relaxation of human pulmonary arteries by PPARγ agonists. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:445-453.
    • Malinowska B., Baranowska-Kuczko M., Schlicker E.: Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? Br J Pharmacol. 2012;165:2073-2088.
    • Baranowska-Kuczko M., Margaret R., MacLean MR., Kozłowska H., Malinowska B.: Endothelium-dependent mechanisms of the vasodilatory effect of endocannabinoid anandamide in the rat pulmonary artery. Pharmacol Res 2012;66:251-259.
    • Rudź R., Schlicker E., Baranowska U., Marciniak J., Karabowicz P., Malinowska B.: Acute myocardial infarction inhibits the neurogenic tachycardic and vasopressor response in rats via presynaptic cannabinoid type 1 receptor. J Pharmacol Exp Ther. 2012;343:198-205.
    • Kozłowska H., Baranowska-Kuczko M., Schlicker E., Kozłowski M., Zakrzeska A., Grzęda E., Malinowska B.: EP3 receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed rats. Pharmacol Rep 2012;64:1526-36.
    • Lupiński S.Ł., Schlicker E., Pędzińska-Betiuk A., Malinowska B.: Acute myocardial ischemia enhances the vanilloid TRPV1 and serotonin 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats. Pharmacol Rep. 2011;63:1450-1459.
    • Malinowska B., Zakrzeska A., Kurz C. M., Göthert M., Kwolek G., Wielgat P., Braszko J. J., Schlicker E.: Involvement of central β2-adrenergic, NMDA and thromboxane A2 receptors in the pressor effect of anandamide in rats. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2010;381:349-360.
    • Zakrzeska A., Schlicker E., Baranowska M., Kozłowska H., Kwolek G., Malinowska B.: A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats. Br. J. Pharmacol. 2010;160:574-584.
    • Günther J., Schulte K., Wenzel D., Malinowska B., Schlicker E.: Prostaglandins of the E series inhibit monoamine release via EP3 receptors: proof with the competitive EP3  receptor antagonist L-826,266. Naunyn Schmiedeberg‘s Arch. Pharmacol. 2010;381:21-31.
    • Pędzińska-Betiuk A., Hryniewicz A., Łupiński S.Ł., Malinowska B.: Nowe aspekty w farmakologii receptorów β-adrenergicznych w niewydolności mięśnia sercowego. Polski Przegląd Kardiologiczny, 2010;12:131-137.