Uniwersytet Medyczny w Białymstoku. Publikacje.
  • Ostatnia zmiana 31.01.2019 przez Klinika Pediatrii, Reumatologii, Immunologii i Chorób Metabolicznych Kości

    Publikacje

    1. Drabinska N, Krupa-Kozak U, Abramowicz P, Jarocka-Cyrta E. Beneficial effect of oligofructose-enriched inulin on vitamin D and E status in children with celiac disease on a long-term gluten-free diet: a preliminary randomized, placebo-controlled nutritional interventional study. Nutrients 2018, 10, 1768; doi:10.3390/nu10111768
    2. Konstantynowicz J, Abramowicz P, Glinkowski W, Taranta E, Marcinowicz L, Dymitrowicz M, Reginster JY, Bruyere O, Beaudart C. Polish Validation of the SarQoL®, a Quality of Life Questionnaire Specific to Sarcopenia. J Clin Med. 2018 Oct 4;7(10). pii: E323. doi: 10.3390/jcm7100323.
    3. Sawicka-Powierza J, Jablonska E, Ratajczak-Wrona W, Rogowska-Szadkowska D, Garley M, Oltarzewska AM, Chlabicz S, Konstantynowicz J. Bone Metabolism Markers and Bone Mineral Density in Patients on Long-Term Acenocoumarol Treatment: A Cross-Sectional Study. J Clin Med. 2018 Oct 20;7(10). pii: E372. doi: 10.3390/jcm7100372.
    4. Midro AT, Stasiewicz-Jarocka B, Borys J, Kozłowski K, Skotnicka B, Tarasów E, Hubert E, Konstantynowicz J, Panasiuk B, Rydzanicz M, Pollak A, Stawiński P, Skowroński R, Płoski R. A 23-year follow-up of a male with Hajdu-Cheney syndrome due to NOTCH2 mutation. Am J Med Genet A. 2018 Oct 17. doi: 10.1002/ajmg.a.40431.
    5. Chlebna-Sokół D, Konstantynowicz J, Abramowicz P, Kulik-Rechberger B, Niedziela M, Obuchowicz A, Ziora K, Karalus-Gach J, Golec J, Michałus I, Karczmarewicz E, Halaba ZP. Evidence of a significant vitamin D deficiency among 9-13-year-old Polish children: results of a multicentre study. Eur J Nutr. 2018 Jun 23. doi: 10.1007/s00394-018-1756-4.
    6. Falkowski M, Maciejczyk M, Koprowicz T, Mikołuć B, Milewska A, Zalewska A, Car H. Whey Protein Concentrate WPC-80 Improves Antioxidant Defense Systems in the Salivary Glands of 14-Month Wistar Rats. Nutrients. 2018 Jun 17;10(6). pii: E782. doi: 10.3390/nu10060782.
    7. Rusińska A, Płudowski P, Walczak M, Borszewska-Kornacka MK, Bossowski A, Chlebna-Sokół D, Czech-Kowalska J, Dobrzańska A, Franek E, Helwich E, Jackowska T, Kalina MA, Konstantynowicz J, Książyk J, Lewiński A, Łukaszkiewicz J, Marcinowska-Suchowierska E, Mazur A, Michałus I, Peregud-Pogorzelski J, Romanowska H, Ruchała M, Socha P, Szalecki M, Wielgoś M, Zwolińska D, Zygmunt A. Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland-Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies-2018 Update. Front Endocrinol (Lausanne). 2018 May 31;9:246. doi: 10.3389/fendo.2018.00246. eCollection 2018. Review
    8. Sawicka-Powierza J, Konstantynowicz J, Jablonska E, Zelazowska-Rutkowska B, Jelski W, Abramowicz P, Sasinowski C, Chlabicz S. The Association Between Long-Term Acenocoumarol Treatment and Vitamin D Deficiency. Front Endocrinol (Lausanne). 2018 May 4;9:226. doi: 10.3389/fendo.2018.00226. eCollection 2018.
    9. Gruszewska E, Sienkiewicz M, Abramowicz P, Konstantynowicz J, Gudowska-Sawczuk M, Chrostek L, Cylwik B. Serum profile of transferrin isoforms in juvenile idiopathic arthritis: a preliminary study. Rheumatol Int. 2018 May 14. doi: 10.1007/s00296-018-4051-z.
    10. Dąbrowska-Leonik N, Bernatowska E, Pac M, Filipiuk W, Mulawka J, Pietrucha B, Heropolitańska-Pliszka E, Bernat-Sitarz K, Wolska-Kuśnierz B, Mikołuć B. Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency. Adv Med Sci. 2018 Mar;63(1):173-178. doi: 10.1016/j.advms.2017.08.001.
    11. Sawicka-Żukowska M, Krawczuk-Rybak M, Bernatowicz P, Muszyńska-Rosłan K, Konstantynowicz J, Łuczyński W. Cardiovascular Risk Factors after Childhood Cancer Treatment Are Independent of the FTO Gene Polymorphism? Int J Endocrinol. 2018 Feb 20;2018:7495234. doi: 10.1155/2018/7495234. eCollection 2018.
    12. Pludowski P, Holick MF, Grant WB, Konstantynowicz J, Mascarenhas MR, Haq A, Povoroznyuk V, Balatska N, Barbosa AP, Karonova T, Rudenka E, Misiorowski W, Zakharova I, Rudenka A, Łukaszkiewicz J, Marcinowska-Suchowierska E, Łaszcz N, Abramowicz P, Bhattoa HP, Wimalawansa SJ. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol. 2018 Jan;175:125-135. doi: 10.1016/j.jsbmb.2017.01.021. Epub 2017 Feb 12.
    13. Bhattoa HP, Konstantynowicz J, Laszcz N, Wojcik M, Pludowski P. Vitamin D: Musculoskeletal health. Rev Endocr Metab Disord. 2017 Sep;18(3):363-371. doi: 10.1007/s11154-016-9404-x. Review
    14. Pietrucha B, Heropolitanska-Pliszka E, Maciejczyk M, Car H, Sawicka-Powierza J, Motkowski R, Karpinska J, Hryniewicka M, Zalewska A, Pac M, Wolska-Kusnierz B, Bernatowska E, Mikoluc B. Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia-Telangiectasia and Nijmegen Breakage Syndrome. Oxid Med Cell Longev. 2017;2017:6745840. doi: 10.1155/2017/6745840.
    15. Witalis E, Mikoluc B, Motkowski R, Sawicka-Powierza J, Chrobot A, Didycz B, Lange A, Mozrzymas R, Milanowski A, Nowacka M, Piotrowska-Depta M, Romanowska H, Starostecka E, Wierzba J, Skorniewska M, Wojcicka-Bartlomiejczyk BI, Gizewska M, Car H; Polish Society of Phenylketonuria. Phenylketonuria patients' and their parents' knowledge and attitudes to the daily diet - multi-centre study. Nutr Metab (Lond). 2017 Aug 17;14:57. doi: 10.1186/s12986-017-0207-1. eCollection 2017.
    16. Maciejczyk M, Mikoluc B, Pietrucha B, Heropolitanska-Pliszka E, Pac M, Motkowski R, Car H. Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome. Redox Biol. 2017 Apr;11:375-383. doi: 10.1016/j.redox.2016.12.030.
    17. Pac M, Bernatowska EA, Kierkuś J, Ryżko JP, Cielecka-Kuszyk J, Jackowska T, Mikołuć B. Gastrointestinal disorders next to respiratory infections as leading symptoms of X-linked agammaglobulinemia in children - 34-year experience of a single center. Arch Med Sci. 2017 Mar 1;13(2):412-417. doi: 10.5114/aoms.2016.60338.
    18. Konstantynowicz J, Marcinowicz L, Abramowicz P, Abramowicz M. What Do Children with Chronic Diseases and Their Parents Think About Pediatricians? A Qualitative Interview Study. Matern Child Health J. 2016 Aug;20(8).
    19. Płudowski P, Ducki C, Konstantynowicz J, Jaworski M. Vitamin D status in Poland. Pol Arch Med Wewn. 2016 Aug 9;126(7-8):530-9.

    20. Marcinowicz L, Abramowicz P, Zarzycka D, Abramowicz M, Konstantynowicz J. How hospitalized children and parents perceive nurses and hospital amenities: A qualitative descriptive study in Poland. J Child Health Care. 2016 Mar;20(1):120-8.

    21. Witalis E, Mikoluc B, Motkowski R, Szyszko J, Chrobot A, Didycz B, Lange A, Mozrzymas R, Milanowski A, Nowacka M, Piotrowska-Depta M, Romanowska H, Starostecka E, Wierzba J, Skorniewska M, Wojcicka-Bartlomiejczyk BI, Gizewska M; Polish Society of Phenylketonuria. Phenylketonuria patients' and their parents' acceptance of the disease: multi-centre study. Qual Life Res. 2016 Nov;25(11):2967-2975.
    22. Kadziela-Olech H, Cichocki P, Chwiesko J, Konstantynowicz J, Braszko JJ. Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD. Eur Child Adolesc Psychiatry. 2015 Jan;24(1):55-63.
    23. Wolska-Kuśnierz B, Gregorek H, Chrzanowska K, Piątosa B, Pietrucha B, Heropolitańska-Pliszka E, Pac M, Klaudel-Dreszler M, Kostyuchenko L, Pasic S, Marodi L, Belohradsky BH, Čižnár P, Shcherbina A, Kilic SS, Baumann U, Seidel MG, Gennery AR, Syczewska M, Mikołuć B et al. Inborn Errors Working Party of the Society for European Blood and Marrow Transplantation and the European Society for Immune Deficiencies.Nijmegen Breakage Syndrome: Clinical and Immunological Features, Long-Term Outcome and Treatment Options - a Retrospective Analysis.  J Clin Immunol. 2015 Aug;35(6):538-49.
    24. Muszynska-Roslan K, Latoch E, Konstantynowicz J, Panasiuk A, Stewart A, Krawczuk-Rybak M. Bone mineral density in pediatric survivors of Hodgkin and non-Hodgkin lymphomas. Adv Med Sci. 2014 Sep;59(2):200-5.
    25. Pludowski P, Grant WB, Bhattoa HP, Bayer M, Povoroznyuk V, Rudenka E, Ramanau H, Varbiro S, Rudenka A, Karczmarewicz E, Lorenc R, Czech-Kowalska J,Konstantynowicz J. Vitamin D status in Central Europe. Int J Endocrinol. 2014; Epub 2014 Mar 26. Review
    26. Kirejczyk JK, Porowski T, Konstantynowicz J, Kozerska A, Nazarkiewicz A, Hoppe B, Wasilewska A. Urinary citrate excretion in healthy children depends on age and gender. Pediatr Nephrol. 2014 Sep;29(9):1575-82
    27. Marcinowicz L, Pawlikowska T, Konstantynowicz J, Chlabicz S. New insight into the role of patients during medical appointments: a synthesis of three qualitative studies. Patient. 2014;7(3):313-8.
    28. Sierpinska T, Konstantynowicz J, Orywal K, Golebiewska M, Szmitkowski M. Copper deficit as a potential pathogenic factor of reduced bone mineral density and severe tooth wear. Osteoporos Int. 2014;25(2):447-54.
    29. Sawicka-Żukowska M, Krawczuk-Rybak M, Muszynska-Roslan K, Panasiuk A, Latoch E, Konstantynowicz J. Does Q223R Polymorphism of Leptin Receptor Influence on Anthropometric Parameters and Bone Density in Childhood Cancer Survivors? Int J Endocrinol. 2013;2013:805312. doi: 10.1155/2013/805312.
    30. Płudowski P, Karczmarewicz E, Bayer M, Carter G, Chlebna-Sokół D, Czech-Kowalska J, Dębski R, Decsi T, Dobrzańska A, Franek E, Głuszko P, Grant WB, Holick MF, Yankovskaya L, Konstantynowicz J et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe - recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol. 2013;64(4):319-27.
    31. Bik-Multanowski M, Kaluzny L, Mozrzymas R, Oltarzewski M, Starostecka E, Lange A, Didycz B, Gizewska M, Ulewicz-Filipowicz J, Chrobot A, Mikoluc B, Szymczakiewicz-Multanowska A, Cichy W, Pietrzyk JJ. Molecular genetics of PKU in Poland and potential impact of mutations on BH4 responsiveness. Acta Biochim Pol. 2013;60(4):613-6.
    32. Głowińska-Olszewska B, Bossowski A, Dobreńko E, Hryniewicz A, Konstantynowicz J, Milewski R, Łuczyński W, Piotrowska-Jastrzębska J, Kowal-Bielecka O. Subclinical cardiovascular system changes in obese patients with juvenile idiopathic arthritis. 2013;2013:436702. doi: 10.1155/2013/436702.
    33. Porowski T, Kirejczyk JK, Konstantynowicz J, Kazberuk A, Plonski G, Wasilewska A, Laube N. Correspondence between Ca²⁺and calciuria, citrate level and pH of urine in pediatric urolithiasis. Pediatr Nephrol. 2013;28(7):1079-84.
    34. Rowczenio DM, Trojer H, Russell T, Baginska A, Lane T, Stewart NM, Gillmore JD, Hawkins PN, Woo P, Mikoluc B, Lachmann HJ. Clinical characteristics in subjects with NLRP3 V198M diagnosed at a single UK center and a review of the literature. Arthritis Res Ther. 2013 Feb 19;15(1):R30. doi: 10.1186/ar4171.
    35. Głowińska-Olszewska B, Tołwińska J, Łuczyński W, Konstantynowicz J, Bossowski A. Cardiovascular risk in nonobese hypertensive adolescents: a study based on plasma biomarkers and ultrasonographic assessment of early atherosclerosis.J Hum Hypertens. 2013 Mar;27(3):191-6.
    36. Muszynska-Roslan K, Panasiuk A, Latoch E, Krawczuk-Rybak M, Konstantynowicz J. Little evidence of low bone mass in acute lymphoblastic leukemia survivors. J Clin Densitom. 2012 Jan-Mar;15(1):108-15.
    37. Konstantynowicz J, Porowski T, Zoch-Zwierz W, Wasilewska J, Kadziela-Olech H, Kulak W, Owens SC, Piotrowska-Jastrzebska J, Kaczmarski M. A potential pathogenic role of oxalate in autism. Eur J Paediatr Neurol. 2012 Sep;16(5):485-91.
    38. Muszynska-Roslan K, Panasiuk A, Latoch E, Krawczuk-Rybak M,Konstantynowicz J. Little evidence of low bone mass in acute lymphoblastic leukemia survivors. J Clin Densitom. 2012 Jan-Mar;15(1):108-15.
    39. Motkowski R, Michalkiewicz J, Mikoluc B, Smolka-Afifi D, Pietrucha B, Kubiszewska I, Piotrowska-Jastrzebska J, Bernatowska E. Peripheral blood T lymphocyte subsets in children with congenital asplenia. Hum Immunol. 2012 Nov;73(11):1091-7.
    40. Mikoluc B, Motkowski R, Karpinska J, Amilkiewicz J, Didycz B, Gizewska M, Lange A, Milanowski A, Nowacka M, Sands D, Schneiberg B, Starostecka E, Wojcicka-Bartlomiejczyk I, Piotrowska-Jastrzebska J. Impact of lipophilic antioxidants and level of antibodies against oxidized low-density lipoprotein in Polish children with phenylketonuria. Antioxid Redox Signal. 2012 Jan 15;16(2):179-82.
    41. Mikoluc B, Michalkiewicz J, Motkowski R, Smolka D, Pietrucha B, Piotrowska-Jastrzebska J, Bernatowska E. Neutrophil phenotypic characteristics in children with congenital asplenia and splenectomized for hereditary spherocytosis. Immunol Invest. 2012;41(1):61-74
    42. Mikoluc B, Motkowski R, Käyhty H, Heropolitanska-Pliszka E, Pietrucha B, Bernatowska E. Antibody response to Haemophilus influenzae type-b conjugate vaccine in children and young adults with congenital asplenia or after undergoing splenectomy. Eur J Clin Microbiol Infect Dis 2012;31:805-809
    43. Mikoluc B, Motkowski R, Karpinska J, Amilkiewicz J, Didycz B, Gizewska M, Lange A, Milanowski A, Nowacka M, Sands D, Schneiberg B, Starostecka E, Wojcicka-BPorowski T, Kirejczyk JK, Zoch-Zwierz W, Konstantynowicz J, Korzeniecka-Kozerska A, Motkowski R, Laube N. Assessment of lithogenic risk in children based on a morning spot urine sample. J Urol. 2010;184(5):2103-8.artlomiejczyk I, Piotrowska-Jastrzebska J. Impact of lipophilic antioxidants and level of antibodies against oxidized low-density lipoprotein in Polish children with phenylketonuria. Antioxid Redox Signal. 2012 Jan 15;16(2):179-82
    44. Konstantynowicz J, Abramowicz P, Jamiolkowski J, Kadziela-Olech H, Bialokoz-Kalinowska I, Kierus-Jankowska K, Piotrowska-Jastrzebska J, Kaczmarski M. Thigh circumference as a useful predictor of body fat in adolescent girls with anorexia nervosa. Ann Nutr Metab 2011; 58:181–187
    45. Konstantynowicz J, Lebensztejn DM, Skiba E, Sobaniec-Lotowska ME, Abramowicz P, Piotrowska-Jastrzebska J, Kaczmarski M. Chronic non-cholestatic liver disease is not associated with an increased fracture rate in children.J Bone Miner Metab. 2011; 29(3):315-32.
    46. Pludowski P, Socha P, Karczmarewicz E, Zagorecka E, Lukaszkiewicz J, Stolarczyk A, Piotrowska-Jastrzebska J, Kryskiewicz E, Lorenc RS, Socha J. Vitamin D supplementation and status in infants: a prospective cohort observational study. J Pediatr Gastroenterol Nutr. 2011 Jul;53(1):93-9.
    47. Bernatowska E, Mikołuć B, Jackowska T, Wolska-Kuśnierz B, Motkowski R. Profilaktyka zakażeń u pacjentów z zaburzeniami odporności - aktualizacja standardów postepowania. Zakażenia 2011; 11, 2A, s. 19-26
    48. Mikołuć B, Bernatowska E, Jackowska T, Motkowski R, Pietrucha B, Pac M, Wolska-Kuśnierz B, Grzesiowski P, Białokoz-Kalinowska I, Piotrowska-Depta M, Piotrowska-Jastrzębska J. Profilaktyka zakażeń u pacjentów z asplenią wrodzoną, po splenektomii lub z dysfunkcją śledziony - aktualizacja standardów postępowania.Standardy Medyczne/Pediatria 2011; 8, 2, s. 227-233.
    49. Heropolitańska-PliszkaE, MikołućB, Rowińska E, Pietrucha B, Motkowski R, Westfal P, Piskorska E, Bernatowska E.Problem of asplenia in a patient with autoimmune polyglandular syndrome type 1. Centr Eur J Immunol 2011; 36(4):256-261
    50. Porowski T, Kirejczyk JK, Zoch-Zwierz W, Konstantynowicz J, Korzeniecka-Kozerska A, Motkowski R, Laube N. Assessment of lithogenic risk in children based on a morning spot urine sample. J Urol. 2010 Nov;184(5):2103-8.
    51. Sierpinska T, Szarmach I, Konstantynowicz J, Szarmach J, Golebiewska M. Reduced systemic bone mineral density associated with a rare case of tooth and nail syndrome. Adv Med Sci. 2010;55(1):111-3.
    52. Porowski T, Kirejczyk JK, Zoch-Zwierz W, Konstantynowicz J, Korzeniecka-Kozerska A, Motkowski R, Laube N. Assessment of lithogenic risk in children based on a morning spot urine sample. J Urol. 2010;184(5):2103-8.
    53. Porowski T, Mrozek P, Sidun J, Zoch-Zwierz W, Konstantynowicz J, Kirejczyk JK, Motkowski R, Laube N. Bonn Risk Index based micromethod for assessing risk of urinary calcium oxalate stone formation. J Urol. 2010 Mar;183(3):1157-62.
    54. Wolska-Kuśnierz B, Mikołuć B, Pietrucha B, Motkowski R, Klaudel-Dreszler M, Heropolitańska-Pliszka E, Bernatowska E. Zespoły gorączek nawrotowych: kiedy podejrzewać? Jak rozpoznawać? Jak leczyć? Pediatria po Dyplomie - Wydanie specjalne, Październik 2010; 42-51
    55. Marcinowicz L, Konstantynowicz J, Godlewski C. Patients' perceptions of GP non-verbal communication: a qualitative study. Br J Gen Pract. 2010 Feb;60(571):83-7.
    56. Porowski T, Konstantynowicz J, Zoch-Zwierz W, Kirejczyk JK, Taranta-Janusz K, Korzeniecka-Kozerska A.Spontaneous urinary calcium oxalate crystallization in hypercalciuric children. Pediatr Nephrol. 2009 Sep;24(9):1705-10.
    57. Muszynska-Roslan K, Konstantynowicz J, Panasiuk A, Krawczuk-Rybak M. Is the treatment for childhood solid tumors associated with lower bone mass than that for leukemia and Hodgkin disease? Pediatr Hematol Oncol. 2009 Jan;26(1):36-47.
    58. Marcinowicz L, Chlabicz S, Konstantynowicz J, Gugnowski Z. Involvement of family nurses in home visits during an 8-year period encompassing primary healthcare reforms in Poland. Health Soc Care Community. 2009 Jul;17(4):327-34.
    59. Mikoluc B, Motkowski R, Karpinska J, Piotrowska-Jastrzebska J. Plasma levels of vitamins A and E, coenzyme Q10, and anti-ox-LDL antibody titre in children treated with an elimination diet due to food hypersensitivity.Int J Vit Nutr Res 79(5),2009,328-336
    60. Mikołuć B, Motkowski R, Amilkiewicz J, Didycz B, Giżewska M, Lange A, Milanowski A, Nowacka M, Schneiberg B, Starostecka E, Wójcicka-Bartłomiejczyk I, Piotrowska-Jastrzębska J. Ocena realizacji zaleceń żywieniowych oraz profilu lipidowego w surowicy krwi dzieci chorych na fenyloketonurię. Pediatria Polska 2009;84(3):217-223
    61. Mikoluc B, Kayhty H, Bernatowska E, Motkowski R. Immune Response to the 7-Valent Pneumococcal Conjugate Vaccine in 30 Asplenic Children. Eur J Clin Microbiol Infect Dis, 2008 Oct;27(10):923-8
    62. Porowski T, Zoch-Zwierz W, Konstantynowicz J, Korzeniecka-Kozerska A, Michaluk-Skutnik J, Porowska H. Reference values of plasma oxalate in children and adolescents. Pediatr Nephrol. 2008 Oct;23(10):1787-94.
    63. Marcinowicz L, Konstantynowicz J, Chlabicz S. The patient's view of the acceptability of the primary care in Poland. Int J Qual Health Care. 2008 Aug;20(4):277-83.
    64. Porowski T, Zoch-Zwierz W, Konstantynowicz J, Taranta-Janusz K. A new approach to the diagnosis of children's urolithiasis based on the Bonn Risk Index.Pediatr Nephrol. 2008 Jul;23(7):1123-8.
    65. Konstantynowicz J, Nguyen TV, Kaczmarski M, Jamiolkowski J, Piotrowska-Jastrzebska J, Seeman E. Fractures during growth: potential role of a milk-free diet.Osteoporos Int. 2007 Dec;18(12):1601-7.
    66. Konstantynowicz J, Kadziela-Olech H, Kaczmarski M, Zebaze RM, Iuliano-Burns S, Piotrowska-Jastrzebska J, Seeman E. Depression in anorexia nervosa: a risk factor for osteoporosis. J Clin Endocrinol Metab. 2005 Sep;90(9):5382-5.
    67. Konstantynowicz J, Białokoz-Kalinowska I, Motkowski R, Abramowicz P, Piotrowska-Jastrzębska J, Sienkiewicz J, Seeman E. The characteristics of fractures in Polish adolescents aged 16-20 years.Osteoporos Int 2005; 16:1397-1403