Działaność naukowa

• Działalność naukowa obejmuje równolegle dwa kierunki badań, tj. badania na poziomie molekularnym mechanizmów wielooporności drobnoustrojów na leki oraz badanie procesów immunoregulacji i pamięci immunologicznej w wybranych chorobach infekcyjnych.
• Epidemiologia zakażeń bakteryjnych
• Zastosowanie nowych metod w diagnostyce mikrobiologicznej

Publikacje
 

• Korczak L, Majewski P, Sacha P, Chludzinska D, Tryniszewska E. Effect of sub-inhibitory tigecycline (½-MIC) on AcrAB-TolC and mar/ram/sox regulatory genes in Enterobacter cloacae complex isolates. Front Cell Infect Microbiol. 2026
• Kuderewska, S., Korczak, Ł., Majewski, P. et al. Assessment of the effect of photodynamic therapy on the reduction of bacteria in deep dental caries lesions of primary teeth. Clin Oral Invest 30, 166 (2026).
• Korczak L, Majewski P, Rombel K, Iwaniuk D, Sacha P, Modzelewski M, Tryniszewska E. In vitro evaluation of tigecycline synergy testing with nine antimicrobial agents against Enterobacter cloacae clinical strains. Front Microbiol. 2024
• Korczak L, Majewski P, Iwaniuk D, Sacha P, Matulewicz M, Wieczorek P, Majewska P, Wieczorek A, Radziwon P, Tryniszewska E. Molecular mechanisms of tigecycline-resistance among Enterobacterales. Front Cell Infect Microbiol. 2024
• Majewski P, Gutowska A, Sacha P, Schneiders T, Talalaj M, Majewska P, Zebrowska A, Ojdana D, Wieczorek P, Hauschild T, Kowalczuk O, Niklinski J, Radziwon P, Tryniszewska E. Expression of AraC/XylS stress response regulators in two distinct carbapenem-resistant Enterobacter cloacae ST89 biotypes. J Antimicrob Chemother. 2020
• Majewski P, Majewska P, Gutowska A, Piszcz J, Sacha P, Wieczorek P, Żebrowska A, Radziwon P, Tryniszewska E. Molecular characterisation of clinical pandrug-resistant Alcaligenes faecalis strain MUB14. Int J Antimicrob Agents. 2020
• Majewski P, Gutowska A, Sacha P, Schneiders T, Talalaj M, Majewska P, Zebrowska A, Ojdana D, Wieczorek P, Hauschild T, Kowalczuk O, Niklinski J, Radziwon P, Tryniszewska E. Expression of AraC/XylS stress response regulators in two distinct carbapenem-resistant Enterobacter cloacae ST89 biotypes. J Antimicrob Chemother. 2020
• Majewski P, Wieczorek P, Łapuć I, Ojdana D, Sieńko A, Sacha P, Kłoczko J, Tryniszewska E. Emergence of a multidrug-resistant Citrobacter freundii ST8 harboring an unusual VIM-4 gene cassette in Poland. Int J Infect Dis. 2017
• Majewski P, Wieczorek P, Ojdana D, Sieńko A, Kowalczuk O, Sacha P, Nikliński J, Tryniszewska E. Altered Outer Membrane Transcriptome Balance with AmpC Overexpression in Carbapenem-Resistant Enterobacter cloacae. Front Microbiol. 2016
• Sacha P, Michalska A, Ojdana D, Wieczorek P, Hauschild T, Majewski P, Tryniszewska E. Identification of plasmid OXA and other β-lactamase genes among carbapenem-resistant isolates of Pseudomonas aeruginosa from the Clinical University Hospital in northeastern Poland. New Microbiol. 2015

• Ojdana D, Safiejko K, Tryniszewska E. Memory T cells subpopulations, generation and maintenance. VDM Verlag Dr. Müller Aktiengesellschaft & Co. KG, Saarbrücken, 2010.
• Sacha P, Wieczorek P, Tryniszewska E. Genes encoding production of metallo-β-lactamases in most important Gram-negative pathogens. W: Current trends in antibiotic resistance in infectious diseases. I. K. International Publishing House Pvt. Ltd., 2009.
• Sacha P, Ostas A, Jaworowska J, Wieczorek P, Ojdana D, Ratajczak J, Tryniszewska E. The KPC type beta-lactamases: new enzymes that confer resistance to carbapenems in Gram-negative bacilli. Folia Histochem Cytobiol. 2009; 47, 4, s. 1-7.
• Boasso A, Vaccari M, Fuchs D, Hardy AW, Tsai W-P, Tryniszewska E, Shearer GM, Franchini G. Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques. J Immunol. 2009; 182: 4313-4320.
• Tryniszewska E, Cecchinato V, Min Ma Z, Vaccari M, Boasso A, Tsai W-P, Petrovas C, Fuchs D, Heraud J-M, Venzon D, Shearer GM, Koup RA, Lowy I, Miller CJ, Franchini G. Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection. J Immunol. 2008; 180 (8): 5439-5447.
• Wieczorek P, Sacha P, Hauschild T, Żórawski M, Krawczyk M, Tryniszewska E. Multidrug resistant Acinetobacter baumannii – the role of AdeABC (RND family) efflux pump in resistance to antibiotics. Folia Histochem Cytobiol. 2008; 46: 257-267.
• Petrovas C, Price DA, Mattapallil, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH,Davis SJ, Franchini G, Koup RA. SIV specific CD8+T-cells express high levels of PD1 and cytokines but have impaired proliferation capacity in acute chronic SIVmac251 infection. Blood. 2007;110: 928-936.