• 23.09.2020 Zakład Chemii Medycznej

    TEACHING PROGRAM

    LECTURES

    Chemistry lectures will be held on line on Thursdays at 15.15 – 16.45 in form of webinars on Blackboard educational platform

    Lecturers: dr hab. Anna Galicka/ dr hab. Iwona Radziejewska

     

    First lecture (2 hours) will be provided on Thursday 1 Oct 2020

     

    Lecture 2   -  8.10.2020

    Lecture 3   -  15.10.2020

    Lecture 4   -  22.10.2020

    Lecture 5   -  29.10.2020

     

     

    LABORATORY CLASSES

    Laboratories take place on Wednesdays and Thursdays in Department of Medical Chemistry

    Teachers: dr hab. Anna Galicka, dr hab. Iwona Radziejewska

     

    Classes start from 14.10.2020

    group 1 – labroom 1; 8.00 - 11.00 (Wednesdays)

    group 2 – labroom 2; 8.00 - 11.00 (Wednesdays)

    group 3 – labroom 1; 8.00 - 11.00 (Thursdays)

    group 4 - labroom 2; 8.00 - 11.00 (Thursdays)

    group 5 - labroom 1; 11.45 - 14.45 (Wednesdays)

    group 6 - labroom 2; 11.45 - 14.45 (Wednesdays)

     

     

    During all laboratory classes students are obliged to change shoes, wear white aprons and protective masks !!

     

    On each laboratory students should have Handouts; they can be printed from the links below

    Starting from Lab 1 students should be prepared - see Problems for preparation

     

    Consulting hours: Mondays 11.00 - 12.00; room 103 (dr hab. Iwona Radziejewska) or in other terms fixed with the teachers

     

     

    Lab 1 (14,15. 10. 2020) (4 hours)

     

    Practical part:

    1. Laboratory regulations and safety rules.
    2. Characteristic reactions of biologically important ions: Na+, K+, Ag+, Ca2+, Ba2+, Cu2+, Fe2+, Fe3+, CO32, SO42, Cl, I, PO43.  Description is presented in a handout - Laboratory 1.

     

    Problems for preparation:.

    1. Elemental composition of inorganic and organic matter. Division, properties and significance of elements in human body. (lecture 1)
    2. Structure, physicochemical properties and significance of water in human organism. Distribution of water and electrolytes in the human body, water-electrolyte equilibrium. (lecture 1)
    3. Main reactions used for detection of biologically important ions (listed above; hand out for Lab 1).

     


     

    Lab 2 (21,22.10.2020) (4 hours)

     

    Practical part:

    1. Calculations of dissociation degree and dissociation constant of weak electrolytes.

    2. Buffer solutions – preparing of buffer solutions, calculating of buffer capacity, examining the influence of buffers dilutions on pH and buffer capacity.

    Description is presented in a handout - Laboratory 2.

    Students should have their own calculators !

     

    Problems for preparation:

    1. Ion constant product of water. Bronstedt-Lowry theory of acids and bases, the strength of acids and bases. Dissociation constant and dissociation degree, pH calculations. Salt hydrolysis. (lecture 1)

    2. Buffers - mechanisms of pH stabilization, buffer capacity. (lecture 1)

    3. The sources and concentration of H+ in extra and intracellular fluids. pH of body fluids and mechanisms responsible for maintaing of acid-base equilibrium. Buffers of the human body. (lecture 1)

    4. Disturbances in acid-base equilibrium (acidosis and alcalosis) and their influence on water-electrolyte metabolism (K+  distribution). (lecture 1)

    5. Calculations – dissociation constant, dissociation degree, pH of electrolytes and buffers, buffer capacity. (examples - hand out 2)

     


     

    Lab 3 (28,29.10.2020) (4 hours)

     

    Practical part:

    1. Alkacymetry as an example of titration - quantitative determination of the amount of strong and weak electrolyte in a solution.

    2. Examination of antioxidative abilities of selected antioxidants.

    Description is presented in a handout - Laboratory 3.

     

    Problems for preparation:

     1. Alkacymetry as an example of titration – indicators, titration curves. (lecture 2)

     2. Solutions – different types of solutions, solubility, types of concentration. (lecture 3)

     3. Calculations - different ways of concentrations expression, calculations based on the results of titration. (lecture 2, 3, hand out 3)

     4. Oxygen free radicals – structure, formation, examples of the effects of their action in the human body and the ways of their elimination. (lecture 2)

     


     

    Lab 4 (4,5.11.2020) (4 hours)

     

    Practical part:

    1. Solutions and theirs properties:

    -       preparing of real solutions

    -       preparation of lyophobic and lyophilic colloid

    -       examination of the protective properties of lyophilic colloids

    -       comparison of the osmotic pressure of real and colloidal solutions

    Description is presented in a handout - Laboratory 4.

     

    Problems for preparation:

    1. Colligative properties of solutions. (lecture 3)

    2. Rault's law and its application. (lecture 3)

    3. Diffusion, osmosis, osmotic and oncotic pressure. Osmotic equilibrium of the organism. (lecture 3)

    4. Colloidal solutions; lyophobic and lyophilic colloids. Colloids of the body, the influence of proteins on distribution of electrolytes in body fluids (Donnan equilibrium). The significance of Donnan equilibrium in processes occuring in living organisms. (lecture 4)

    5. Calculations (examples presented in hand out 4)

     


     

    Lab 5  (18,19.11.2020) (4 hours)

     

    Practical part:

              1. Detection of functional groups in organic compounds (multiple bonds, alcohols and phenols, aldehydes, carboxylic acids, ketones, amines. 

                Description is presented in a handout -   Laboratory 5

     

    Problems for preparation (lecture 5):

                  Selected biologically important organic compounds

    - aromatic hydrocarbons, heterocyclic compounds and their derivatives in vitamins, drugs and macromolecules

    - carbohylic acids: hydroxyacids, ketoacids, saturated and unsaturated fatty acids, essential unsaturated fatty acids

    - carbohydrates (isomers, glycosidic bonds, derivatives of simple carbohydrates, chemical properties)

     

     Requirements for lab test 5

     

     

     


     

    Final Test (exact date will be fixed with the students) (2 hours)

     

    The final test includes subjects from lectures and classes.

    Examples of calculations are in Handouts for Laboratory 2, 3 and 4.

     

    Students should have calculators for final test. Using mobile phones for calculations is strictly forbidden !