PhD students will be involved in a research project implemented at the Department of Regenerative Medicine and Immune Regulation, MUB, aimed at clarifying immunological mechanisms, both cellular and molecular, involved in the development and progression of different cancers, including lung cancer, melanoma, breast cancer and haematological disorders. The research projects will include: a) Evaluation of the role of selected miRNAs on the function of tumour associated macrophages; b) Analysis of the role of selected miRNAs on the immune-modulatory effects of tumor cells; c) Evaluation of systemic pro- and anti- inflammatory responses in lung cancer patients; d) Prospective evaluation of new prognostic factors in patients with haematological malignancies; e) Analysis of the role of novel pattern recognition receptors, namely AIM-like receptors, RIG-like receptors, NOD-like receptors and Toll-like receptors in cancer progression and development; f) Assessment of immunomodulatory properties of different nanoparticles and their possible implication in cancer treatment; g) Assessment effects of SOX2 transcription factor in tumour cells on tumour-infiltrating immune cells phenotype and function; h) Assessment of novel targets of cancer therapy - role of miRNA in cancer maintenance, progression and spread.
MUB Expert: professor Marcin Moniuszko