MUB scientists investigated the role of inflammatory mediators such as matrix metalloproteinases, their tissue inhibitors and YKL-40 in the diagnosis of patients with dementing disorders. Promising preliminary results are encouraging MUB’s researchers to carry on further studies so the goal of future PhD theses will be the assessment of concentrations of selected proinflammatory biomarkers in serum and cerebrospinal fluid of patients with mild cognitive impairment (MCI), AD and cognitively normal subjects. PhD students will use ELISA method (Eti-Max analyzers, DiaSorin) and multiplexing techniques (Luminex 200 / MESO QuickPlex SQ 120 analysers) to assess the concentration of particular proteins. Students will compare concentration of tested substances with classic NDD biomarkers (Aβ-42, Aβ-40, Tau, pTau181). New biochemical markers may be helpful in the early recognition of an ongoing neuropathological process. Novel biomarkers could be valuable for improving early disease diagnosis, characterizing prognostic factors and may predict progression of dementing disorders.
MUB Expert: professor Barbara Mroczko