The main purpose of scientific research project for PhD studies in molecular biology area will be concentrated on genomic, transcriptomic and epigenomic studies on tumor cells and tissues. Modern technologies like quantitative real-time PCR, microarrays and next generation sequencing will be used in the studies, based on the equipment present in MUB laboratories and bioinformatics support. These include comparative genomic hybridization, whole genome and targeted sequencing, mRNA and small RNA profiling by microarray analysis and next generation sequencing, epigenomic analysis by reduced representation bisulfite sequencing. Using these novel techniques we are going to detect disturbances in the structure and functions of genomes, responsible for neoplastic transformation, invasion properties of tumor cells, and their ability to form metastases. We also plan to perform studies of the possible impact of different environmental factors (like viral, bacterial and fungal infections, diet, cigarette smoking) on cancer development and progression at molecular level.