I am currently working on the project “The role of hepatic aquaporins in the fatty acid-induced accumulation of bioactive lipids and insulin resistance in HepG2 liver cells”.
Despite the clear correlation between obesity and type 2 diabetes the actual mechanism of obesity-induced insulin resistance is not fully elucidated. We are trying to understand if aquaporin proteins - membrane channels interested in the trafficking of water and other small molecules– take part in this process. Indeed aquaporins are present both in adipocytes and hepatocytes and are involved in the passage, between others molecules, of glycerol – an important constituent of intracellular lipids. We are examining if the accumulation of bioactive lipids (ceramides and diacylglycerols) in hepatocytes, induced by a fatty acid load, is linked to the function of one or more aquaporins. We are also investigating aquaporins involvement in insulin resistance development, checking if their modulation influence hepatocytes glucose metabolism and insulin sensitivity. This study will be performed with a proteomics approach, which aims to discover new targets useful in the diabetes research.
Department: Department of Medical Biology
Supervisor: Piotr Zabielski, Ph.D., D.Sc., assistant professor, Head of the Department of Medical Biology
- Piotr Zabielski, Ph.D., D.Sc., assistant professor, Head of the Department of Medical Biology
- Agnieszka U. Blachnio-Zabielska, Ph.D., D.Sc., assistant professor, Head of the Department of Hygiene, Epidemiology and Metabolic Disorders
- Arkadiusz Żbikowski, MSc, assistant, Department of Medical Biology
Hi! I am Mauro Galli and I am an Italian Ph.D. student enrolled in the “ImPRESS HORIZON 2020 cofund doctoral program” held at the Medical University of Białystok. I studied Industrial Biotechnology at the University of Milano-Bicocca where I built a multidisciplinary curriculum. During my bachelor degree I had an internship in the biochemistry laboratory of the IBSA SA company in Switzerland. Despite the opportunity to continue in this company, I preferred to face up to a new challenge during the MSc degree. I had my undergraduate period in the “Protein transport and secretion” lab at the San Raffaele Scientific Institute in Milan, where I had opportunity to work with several distinguished researchers. I worked in the field of redox biology, studying mainly aquaporin 8 and its role in signalling as an hydrogen peroxide channel. I spent two years after my thesis as a research fellow in the same lab, working on this fascinating aquaporin world and taking part in the discovery of the oxidative stress-related closure mechanism of aquaporin 8. In 2018 I started my Ph.D. in the exciting environment of the Medical University of Białystok, focusing on diabetes and insulin resistance. If you want to get in touch with me and have a scientific chat or if you have something to propose, just write me an email.