Project: Is clonal hematopoiesis of indeterminate potential (CHIP) a predictive biomarker of atherosclerosis in Ischemic heart disease patients?
Department : Department of Population Medicine and Civilization Diseases Prevention
Principle Investigator’s Supervisor : Prof. dr hab. med. Karol Kamiński
Co-investigators : Dr Pawel Sowa
Research background (first year PhD PROJECT 2018/2019)
Clonal hematopoiesis of indeterminate potential (CHIP), which, defined as the presentation of mutant clones of white blood cells due to somatic mutation in persons without hematologic disorder, may serve as a risk factor for atherosclerotic cardiovascular disease. However, the nature of this association is still unclear. We intended to identify pathologies associated with presentation of clonal hematopoiesis of indeterminate potential (CHIP) in patients with Ischemic heart disease (IHD). We will perform amplicon sequencing to detect the present of CHIP in peripheral blood mononuclear cells (PBMC) and relate such presence with a risk factor of cardiovascular disease in patients with ischemic heart disease.
cardiovascular disease, cardiac rehabilitation, breast cancer, epidemiology, biostatistics and breast cancer