Project 2021-2022: The utility of polygenic risk scores for type 2 diabetes and related traits, in prediction of metabolic changes.
Principal Investigator's Supervisor: Prof. Dr hab. Adam Krętowski and Dr. Lukasz Szczerbiński
Department: Clinical Research Centre
Contact:
Abstract:
Type 2 diabetes and its precursor prediabetes, affect 8% and 7% of the world’s population, respectively. The number of studies combining phenotypic and genetic variables to predict the diabetes risk increases as showing generally promising results (polygenic risk scores). Recent studies have shown that patients with prediabetes can suffer from coronary artery disease and diastolic heart failure even before progressing to overt diabetes. However the prediabetes can be controlled with change of habits. With this knowledge, identify patients with prediabetes and take appropriate measures to optimize glycemic control is essential. To address this, the current research propose an approach to associate genetic information and metabolic traits related to diabetes and metabolic syndrome development. This could provide a powerful tool to prevent T2D development and metabolic syndrome complications, identifying individuals with increased risk and defining a kickoff towards precision medicine in diabetes.
Background and Research Interest:
Biotechnology, Diabetes, Genomics, Health Care, Bioinformatics, Data Analysis.
Biography:
¡Hola! I’m Luis Felipe Padilla-Martínez, from Guanajuato, México. I studied the bachelor in Experimental Biology in the University of Guanajuato, graduated in 2015. During my bachelor I made a stay in The University of Arizona, completing the Latin American Summer Research Program. In 2015 I was accepted to do my Master’s degree in the Center for Research and Assistance in Technology and Design of the State of Jalisco AC (CIATEJ). I made a research stay during my master degree at the Autonomous University of Barcelona, in the institute of biotechnology and biomedicine where I learned to use bioinformatics tools for genomic analysis.
Right now I’m a fourth year PhD student enrolled in the “ImPRESS HORIZON 2020 cofund doctoral program” held at the Medical University of Białystok.