The competition under the program "Student science organizations create innovations" has been resolved. The Minister of Education and Science selected 128 projects for financing for the total amount of PLN 6 590 695. The winners were selected from among 244 applicants. Two Scientific MUB student organizations received funding for their research.
The project "Could naproxen be a new antidiabetic drug? Pre-clinical studies on an animal model" was prepared by the Student Scientific Organization "Biochemistry of Civilization Diseases" at the Department of Hygiene, Epidemiology and Ergonomics of the Medical University of Bialystok - fifth-year students of Medicine - Cezary Pawlukianiec, Małgorzata Gryciuk and Kacper Mil. Experimental studies conducted by this organization focus on the assessment of the antiglyco-oxidative properties of drugs. Protein glycation and oxidation play a key role in the pathogenesis of many modern civilization diseases, which are important problems of public health. Particularly noteworthy, however, is the role of protein glycation in the development of late diabetes complications. Therefore, there is an intense search for compounds inhibiting protein glycoxidation. Among the substances tested so far, the strongest anti-glycation effect has been confirmed in aminoguanidine. However, due to its high toxicity, this compound has not passed clinical trials and cannot be used in medical practice. Therefore, drugs commonly used in therapy are becoming more and more popular in research. Their safety profile and pharmacological properties are well known and therefore these drugs can be used in additional therapeutic indications. The scientific supervisor of the project and the editor of the application is dr Mateusz Maciejczyk.
The other project prepared by the fifth-year students of Medicine: Paulina Mieleszko, Krzysztof Krajewski and Mateusz Lipiński got the grant. Students from the student scientific organization at the Department of Rheumatology and Internal Medicine under the supervision of prof. Otylia Kowal-Bielecka, prepared a study entitled "To evaluate the importance of CA 19-9, PRDX4, and osteopontin as new predictors of ILD progression in systemic scleroderma." Systemic scleroderma is a chronic disease of connective tissue with an unpredictable, often severe course, the pathogenesis and treatment of which are still the subject of intensive research. The most common cause of death in patients with this disease is a decrease in respiratory efficiency due to pulmonary fibrosis in the course of interstitial disease. In clinical practice, it is important to be able to identify patients at risk of faster progression of interstitial disease, as these patients should be qualified for early, aggressive treatment. Currently, the identification of such patients is very difficult. Based on the analysis of the available literature, students identified 3 molecules that seem to be potential attractive prognostic indicators of interstitial lung disease in patients with systemic scleroderma.