A prospective study of pediatric patients treated with combined laser therapy because of overgrown burn scars was conducted in 2019. During one year, over 50 patients with burn scars were treated.
The uniqueness of this survey is that pulsed dye laser (PDL) and ablative fractional CO2 laser (CO2-AFL) were used simultaneously, and authors assessed cosmetic results and measured biochemical markers in the serum of patients. Already one session of combined pulsed dye laser (PDL) and ablative fractional CO2 laser therapy improved pliability, decreased height, vascularity and pigmentation of burn scars. Moreover, both younger and older children have the same benefit from combined laser treatment. Laboratory results correlated with clinical observations. The levels of metalloproteinase II (MMP-2) and tissue inhibitor of metalloproteinase I (TIMP-1) and type I collagen in studied patients with scars before laser treatment were higher in comparison to controls. The authors also found a statistically significant decrease in the levels of metalloproteinases after laser treatment of burn scars, which can indicate reduced dynamic of a scar. After laser treatment, there was also downward trend in the plasma level of type I collagen, but without statistical significance. According to this study, combined pulsed dye laser and ablative fractional CO2 laser treatment are safe. The authors did not observe adverse effects.
Conclusions: this study clearly shows that combined CO2-AFL treatment for burn scars improves texture, colour, function and alleviate pruritus. The decline of MMP-2, TIMP-1 and type I collagen concentrations caused by laser treatment probably reproduce reduced dynamic of a scar.
Effects of combined Pulsed Dye Laser and Fractional CO 2 Laser treatment of burn scars and correlation with plasma levels of collagen type I, MMP-2 and TIMP-1