Founded in 1999 CNICs mission is to improve cardiovascular health in the general population by generating scientific knowledge, efficiently translating that knowledge to the clinic, and providing new researchers with comprehensive training. It was awarded with the “Severo Ochoa” distinction by the Spanish government in recognition of its leading international standing in cardiovascular research. The CNIC building has the capacity to house over 500 scientists and is fitted with the latest generation of technological equipment. The international reach is a real achievement with successful strategic alliances and strong links with academia, i.e.: Mount Sinai School of Medicine (New York, USA), Tufts University (Massachusetts, USA), Ferrer International, Philips Healthcare, etc. The CNIC Technical Units provide key scientific services; core support facilities include proteomics, genomics, cellomics, dynamic and quantitative microscopy, bioinformatics, gene targeting, viral vectors, transgenesis and cell culture suites. For research involving animals, CNIC has one of the most modern animal facilities in Europe. Since 2004 it has attracted more than 25 M€ from international competitive sources, and c. 50 M€ from national funds. Although CNIC has only 33 research groups it participated in 29 projects funded under FP7 and 9 H2020 projects. 21 Marie Curie projects have been awarded to CNIC including 2 coordinated ITNs and 2 COFUND projects. 5 ERC projects were awarded to CNIC under FP, and 2 under H2020 (ANGIOGenesHD & YOUNGatHEART). CNIC coordinates 3 HEALTH projects: FOCUS (FP7), CARE-MI (FP7), SECURE (H2020), and participates in 4 others as a partner (2 in H2020). CNIC has an experience of participation in COST actions, and obtaining important private international funding from i.e. Howard Hughes Medical Institute, Bayer, and Progeria. Training is one of the CNICs principal areas of activity. The Centre’s training activities are coordinated within the CNIC-JOVEN Training Plan, which includes programmes at all levels from secondary education to the training of postdoctoral researchers such as training programmes for young Medical Professionals (Res@cnic; CARDIO-IMAGE, CardioJoven; INVESMIR); for bachelor students (International PhD Programme CNIC-La Caixa; Predoctoral Programme, Master Programme; Cardiovascular Postgraduate Programme); undergraduate programmes (CICERONE and ACERCATE). In 2014 around 500 people have been enrolled in the different training programmes and workshops. Current international projects dedicated to training: COFUND CNIC-IPP for the recruitment of postdoctoral researchers; COFUND CNIC-IIF for the recruitment of group leaders; ITNs coordinated projects (ITN-IDT-2013. CardioNext. ITN-2011. CardioNet), and 3 ITNs as a Partner.